DCM offers considerable expertise, equipment and specialized space to support your in-vivo projects. Collectively, DCM’s management team offers over 100 years of experience in the field of lab animal science, medicine and surgery. We can provide consulting, surgical or technical support and welcome collaboration with you in all phases of your project from development to implementation.
DCM’s professional staff is available to provide you with a full range of technical support to your projects, from day-to-day maintenance of mouse colonies to intensive management and performance of all animal work as designed by you or in collaboration with our management team.
My lab is interested in the role that the hormonal peptides glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) play in regulating growth and function of beta-cells and the intestinal tract. Over multiple projects, DCM staff has provided expert advice in terms of developing protocols and endpoints, appropriate monitoring of animal health during a study and trouble-shooting techniques during an experiment. A number of graduate students have relied on DCM advice for completion of their experiments. We have always found DCM to be most supportive and a true pleasure to work with.
Dr. Patricia Brubaker
Departments of Physiology and Medicine
Canada Research Chair (Tier 1) in Vascular and Metabolic Biology
My lab is interested in evaluating the impact of fluorinated pollutants on people and the environment. When we have needed to perform in vivo experiments, my lab staff has often consulted with DCM veterinarians and technicians. In one of our more recent projects, DCM veterinary technicians provided technical expertise in the administration of a fluorinated compound and in the subsequent blood collection to evaluate its presence within the body. They were very organized and easy to collaborate with. Their help allowed us to successfully collect data to further our evaluation of these compounds.
Dr. Scott Mabury
Department of Chemistry
Professor of Environmental Chemistry
Vice-President University Operations
My lab is interested in improving the surface design of implants help to stimulate bone healing. We surgically place coated implants and evaluate how well those coating stimulate healing around the implants. DCM veterinary technologists have been critical to our success in these projects. They help us monitor the anesthesia, perform the preparation of the surgical site and administer the appropriate analgesics. Their help has allowed us to perform multiple procedures efficiently, and with the highest standards of animal care.
Dr. John Davies
Faculty of Dentistry
Institute of Biomaterials & biomedical Engineering
My team has developed lecithin-based microemulsion drug delivery platforms that could be used in a variety of delivery routes, including oral. Although our in vitro data makes a compelling case, development into products requires in vivo confirmation of safety and efficacy. As my team had no in vivo experience, we met with DCM veterinarians to design a testing program for oral delivery safety and efficacy. Their guidance was instrumental in developing the in vivo evaluation part of a Connaught Innovation Award proposal that funded our studies. Their help was also key in developing the ethics protocols for these studies. DCM veterinary technologists were responsible for administering the compounds, collecting blood and then tissues at the end of the experiment. DCM also put us in contact with a veterinary pathologist who was able to examine tissues for any pathological changes that may be linked to our microemulsion system. We were very satisfied with the services DCM performed for us. They communicated with us frequently and were very responsive to our needs. I see the DCM team as partners in my research, a welcoming team ready to listen and provide timely input.
Professor Edgar Acosta
Department of Chemical Engineering and Applied Chemistry
Qin T., Liang T., Zhu, D., Kang, Y., Xie, L., Dolai, S., Sugita, S., Takahashi, N., Ostenson, C-G., Banks K., and Gaisano. H.Y. (2017) Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis. EbioMedicine, dx.doi.org/10.1016/j.ebiom.2017.01.030.
Collymore, C., Banks, E.K. and Turner, P.V. (2016) Lidocaine Hydrochloride vs MS222 for the Euthanasia of Zebrafish (Danio rerio). Journal of the American Association for Laboratory Animal Science, 55(6): 816-820.
Mohamed, M.A., Raeesi, V., Turner, P.V., Rebbapragadam, A., Banks, K., and Chan, W.C.W. (2016) A versatile plasmonic thermogel for disinfection of antimicrobial resistant bacteria. Biomaterials, 97: 154-163.
Yang, K., Fard, S., Lip H-Y, Furrer R., Archer M.C., Bruce W. R., Lip, H., Mehta R., O’Brien P. J., Giacca A., Ward W. E., Femia P., Caderni G., Medline A., and Banks K. (2016) Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings. Nutrition and Cancer, 68(1), 94-104.
Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B, Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish, 13 Suppl 1:S153-63.
Banks K., Qin T., Liang T., and Gaisano. H.Y. (2014) Biliopancreatic route for effective viral transduction of pancreatic islets. Pancreas, 43(2), 240-244.
Collymore C., Kent L., Ahn S.K., Xu W., Li M., Liu J., Turner P.V., Banks E.K. Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research. (2018) Comparative Medicine, 68(1):41-47
Acknowledgements of DCM Staff: